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A preliminary study evaluating diabetic peripheral neuropathy has demonstrated that targeted supplementation with these active B-vitamins (along with pyridoxal 5'-phosphate) can actually increase epidermal nerve fiber density, meaning the nerves physically begin to regrow and heal, leading to a reduction in pain and paresthesia

This fragment-based approach is what differentiates AOD-9604 from GHRH analogs such as Tesamorelin, which act upstream in the pituitary rather than directly on metabolic pathways

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Dehydration can be a major trigger for migraines